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Article

Stabilisation of the Fc fragment of human IgG1 by engineered intradomain disulfide bonds.

PloS one - 1 Jan 2012

Wozniak-Knopp Gordana, Stadlmann Johannes, Rüker Florian

Abstract excerpt

We report the stabilization of the human IgG1 Fc fragment by engineered intradomain disulfide bonds. One of these bonds, which connects the N-terminus of the CH3 domain with the F-strand, led to an increase of the melting temperature of this domain by 10°C as compared to the CH3 domain in the con...

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Identifiers

PMID: 22272277
DOI: 10.1371/journal.pone.0030083
PMCID: PMC3260182

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22272277-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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