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Article

Complementary MS methods assist conformational characterization of antibodies with altered S-S bonding networks.

Journal of the American Society for Mass Spectrometry - 1 Jun 2013

Jones Lisa M, Zhang Hao, Cui Weidong, Kumar Sandeep, Sperry Justin B, Carroll James A, Gross Michael L

Abstract excerpt

As therapeutic monoclonal antibodies (mAbs) become a major focus in biotechnology and a source of the next-generation drugs, new analytical methods or combination methods are needed for monitoring changes in higher order structure and effects of post-translational modifications. The complexity of these molecules and their vulnerability to structural change provide a serious challenge. We describe here the use of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23483515
DOI: 10.1007/s13361-013-0582-4
PMCID: PMC3651811

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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