Photoinduced Trp and Tyr Side Chain Cleavage in IgG4-Fc: Impact on Physicochemical Stability and Receptor Binding and Effect of N- vs O-Glycosylation.

Abstract excerpt

In previous studies, we discovered that the exposure of IgG4-Fc and IgG1 to UV light resulted in the side chain cleavage of specific Tyr and Trp residues, converting these amino acids into a series of products, including Gly [Haywood, J. Mol. Pharmaceutics 2013, 10(3), 1146-1150; Kang, H. Mol. Pharmaceutics 2019, 16, 258-272]. In order to evaluate the physicochemical consequences of such photochemical...

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