Article
Allelic imbalance analysis by high-density single-nucleotide polymorphic allele (SNP) array with whole genome amplified DNA.
Nucleic acids research - 17 May 2004
Wong Kwong-Kwok, Tsang Yvonne T M, Shen Jianhe, Cheng Rita S, Chang Yi-Mieng, Man Tsz-Kwong, Lau Ching C
Abstract excerpt
Besides their use in mRNA expression profiling, oligonucleotide microarrays have also been applied to single-nucleotide polymorphism (SNP) and loss of heterozygosity (LOH) or allelic imbalance studies. In this report, we evaluate the reliability of using whole genome amplified DNA for analysis with an oligonucleotide microarray containing 11 560 SNPs to detect allelic imbalance and chromosomal copy number...
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