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Article

An integrated view of copy number and allelic alterations in the cancer genome using single nucleotide polymorphism arrays.

Cancer research - 1 May 2004

Zhao Xiaojun, Li Cheng, Paez J Guillermo, Chin Koei, Jänne Pasi A, Chen Tzu-Hsiu, Girard Luc, Minna John, Christiani David, Leo Chris, Gray Joe W, Sellers William R, Meyerson Matthew

Abstract excerpt

Changes in DNA copy number contribute to cancer pathogenesis. We now show that high-density single nucleotide polymorphism (SNP) arrays can detect copy number alterations. By hybridizing genomic representations of breast and lung carcinoma cell line and lung tumor DNA to SNP arrays, and measuring locus-specific hybridization intensity, we detected both known and novel genomic amplifications and homozygous...

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Source

Identifiers

PMID: 15126342
DOI: 10.1158/0008-5472.can-03-3308

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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