Article
A putative zinc finger protein, Saccharomyces cerevisiae Vps18p, affects late Golgi functions required for vacuolar protein sorting and efficient alpha-factor prohormone maturation.
Molecular and cellular biology - 1 Dec 1991
Robinson J S, Graham T R, Emr S D
Abstract excerpt
Saccharomyces cerevisiae strains carrying vps18 mutations are defective in the sorting and transport of vacuolar enzymes. The precursor forms of these proteins are missorted and secreted from the mutant cells. Most vps18 mutants are temperature sensitive for growth and are defective in vacuole bi...
Topics
- Adaptor Proteins, Vesicular Transport
- Amino Acid Sequence
- Base Sequence
- Binding Sites
- DNA, Fungal
- Fungal Proteins
- Genetic Complementation Test
- Genomic Library
- Golgi Apparatus
- Hydrolases
- Membrane Proteins
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Phenotype