Article
Compartmental organization of Golgi-specific protein modification and vacuolar protein sorting events defined in a yeast sec18 (NSF) mutant.
The Journal of cell biology - 1 Jul 1991
Graham T R, Emr S D
Abstract excerpt
The sec18 and sec23 secretory mutants of Saccharomyces cerevisiae have previously been shown to exhibit temperature-conditional defects in protein transport from the ER to the Golgi complex (Novick, P., S. Ferro, and R. Schekman, 1981. Cell. 25:461-469). We have found that the Sec18 and Sec23 protein functions are rapidly inactivated upon shifting mutant cells to the nonpermissive temperature (less than 1 min)....
Topics
- Animals
- Biological Transport
- Fungal Proteins
- Golgi Apparatus
- Mutation
- Saccharomyces cerevisiae
- Vacuoles