Novel syntaxin homologue, Pep12p, required for the sorting of lumenal hydrolases to the lysosome-like vacuole in yeast.

doi:10.1091/mbc.7.4.579

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Article

Novel syntaxin homologue, Pep12p, required for the sorting of lumenal hydrolases to the lysosome-like vacuole in yeast.

Molecular biology of the cell - 1 Apr 1996

Becherer K A, Rieder S E, Emr S D, Jones E W

Abstract excerpt

pep12/vps6 mutants of Saccharomyces cerevisiae are defective in delivery of soluble vacuolar hydrolases to the vacuole. Morphological analysis by electron microscopy revealed that pep12 cells accumulate 40- to 50-nm vesicles. Furthermore, pep12 cells have enlarged vacuoles characteristic of class...

Topics

Amino Acid Sequence
Animals
Centrifugation, Density Gradient
Cloning, Molecular
Conserved Sequence
Endosomes
Fungal Proteins
Gene Deletion
Hydrolases
Membrane Proteins
Molecular Sequence Data
Phenotype
Qa-SNARE Proteins
Rats
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Vacuoles

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Identifiers

PMID: 8730101
DOI: 10.1091/mbc.7.4.579
PMCID: PMC275911

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8730101-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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