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Article

Functional characterization of the atopy-associated gene PHF11.

The Journal of allergy and clinical immunology - 1 May 2008

Clarke Emily, Rahman Nusrat, Page Natalie, Rolph Michael S, Stewart Graeme J, Jones Graham J

Abstract excerpt

BACKGROUND: Polymorphisms in the plant homeodomain finger protein 11 gene (PHF11) are associated with increased total serum IgE levels, asthma, and severe atopic dermatitis (AD) in children. Although PHF11 includes a plant homeodomain, a motif often found in transcriptional regulators, the function of PHF11 has not been investigated. OBJECTIVE: We sought to test (1) whether PHF11 regulates the transcription of...

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Source

Identifiers

PMID: 18405956
DOI: 10.1016/j.jaci.2008.02.028

Genes

PHF11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Functional characterization of the atopy-associated gene PHF11.PMID 18405956Read ↗

Allele-specific transcription of the asthma-associated PHD finger protein 11 gene (PHF11) modulated by octamer-binding transcription factor 1 (Oct-1).Semantic proximity Read ↗

Polymorphisms within the PHF11 gene at chromosome 13q14 are associated with childhood atopic dermatitis.Semantic proximity Read ↗

Polymorphisms of PHF11 and DPP10 are associated with asthma and related traits in a Chinese population.Semantic proximity Read ↗

PHF11 is not a major candidate gene for asthma or eczema in Chinese children.Semantic proximity Read ↗

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The PHF11 gene is not associated with asthma or asthma phenotypes in two independent populations.Semantic proximity Read ↗

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Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma.Semantic proximity Read ↗

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PHF11 expression and cellular distribution is regulated by the Toll-Like Receptor 3 Ligand Polyinosinic:Polycytidylic Acid in HaCaT keratinocytes.Semantic proximity Read ↗

HLX1 gene variants influence the development of childhood asthma.Semantic proximity Read ↗

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