Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma.

doi:10.1038/ng1166

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma.

Nature genetics - 1 Jun 2003

Zhang Youming, Leaves Nicholas I, Anderson Gavin G, Ponting Chris P, Broxholme John, Holt Richard, Edser Pauline, Bhattacharyya Sumit, Dunham Andy, Adcock Ian M, Pulleyn Louise, Barnes Peter J, Harper John I, Abecasis Gonçalo, Cardon Lon, White Melanie, Burton John, Matthews Lucy, Mott Richard, Ross Mark, Cox Roger, Moffatt Miriam F, Cookson William O C M

Abstract excerpt

Atopic or immunoglobulin E (IgE)-mediated diseases include the common disorders of asthma, atopic dermatitis and allergic rhinitis. Chromosome 13q14 shows consistent linkage to atopy and the total serum IgE concentration. We previously identified association between total serum IgE levels and a novel 13q14 microsatellite (USAT24G1; ref. 7) and have now localized the underlying quantitative-trait locus (QTL) in a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Asthma

Share to Chromosomes, Human, Pair 13

Share to Haplotypes

Share to Immunoglobulin E

Share to Quantitative Trait Loci

Share to Tissue Distribution

Share to Zinc Fingers

Source

Open in PubMed

Identifiers

PMID: 12754510
DOI: 10.1038/ng1166

Genes

PHF11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma.PMID 12754510Read ↗

Polymorphisms within the PHF11 gene at chromosome 13q14 are associated with childhood atopic dermatitis.Semantic proximity Read ↗

A functional AT/G polymorphism in the 5'-untranslated region of SETDB2 in the IgE locus on human chromosome 13q14.Semantic proximity Read ↗

Positional cloning of a novel gene influencing asthma from chromosome 2q14.Semantic proximity Read ↗

DNA methylation loci associated with atopy and high serum IgE: a genome-wide application of recursive Random Forest feature selectionSemantic proximity Read ↗

An allergy-associated polymorphism in a novel regulatory element enhances IL13 expression.Semantic proximity Read ↗

Chromosome 11q13 and atopic asthma.Semantic proximity Read ↗

Fine-mapping of IgE-associated loci 1q23, 5q31, and 12q13 using 1000 Genomes Project data.Semantic proximity Read ↗

Allele-specific transcription of the asthma-associated PHD finger protein 11 gene (PHF11) modulated by octamer-binding transcription factor 1 (Oct-1).Semantic proximity Read ↗

The gene encoding interleukin-13: a susceptibility locus for asthma and related traits.Semantic proximity Read ↗

Fine mapping and positional candidate studies on chromosome 5p13 identify multiple asthma susceptibility loci.Semantic proximity Read ↗

Interleukin-4 and interleukin-13 pathway genetics affect disease susceptibility, serum immunoglobulin E levels, and gene expression in asthma.Semantic proximity Read ↗

A polymorphism in the TH 2 locus control region is associated with changes in DNA methylation and gene expression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.