Article
Heat shock protein 70 chaperone overexpression ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model by reducing nuclear-localized mutant androgen receptor protein.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Mar 2003
Adachi Hiroaki, Katsuno Masahisa, Minamiyama Makoto, Sang Chen, Pagoulatos Gerassimos, Angelidis Charalampos, Kusakabe Moriaki, Yoshiki Atsushi, Kobayashi Yasushi, Doyu Manabu, Sobue Gen
Abstract excerpt
Spinal and bulbar muscular atrophy (SBMA) is an inherited motor neuron disease caused by the expansion of the polyglutamine (polyQ) tract within the androgen receptor (AR). The nuclear inclusions consisting of the mutant AR protein are characteristic and combine with many components of ubiquitin-...
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