Article
Phenotypic plasticity of neoplastic ovarian epithelium: unique cadherin profiles in tumor progression.
Clinical & experimental metastasis - 1 Jan 2008
Hudson Laurie G, Zeineldin Reema, Stack M Sharon
Abstract excerpt
The mesodermally derived normal ovarian surface epithelium (OSE) displays both epithelial and mesenchymal characteristics and exhibits remarkable phenotypic plasticity during post-ovulatory repair. The majority of epithelial ovarian carcinomas (EOC) are derived from the OSE and represent the most lethal of all gynecological malignancies, as most patients (approximately 70%) present at diagnosis with disseminated...
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