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Article

Heterogeneous Cadherin Expression and Multicellular Aggregate Dynamics in Ovarian Cancer Dissemination.

Neoplasia (New York, N.Y.) - 1 Jul 2017

Klymenko Yuliya, Johnson Jeffrey, Bos Brandi, Lombard Rachel, Campbell Leigh, Loughran Elizabeth, Stack M Sharon

Abstract excerpt

Epithelial ovarian carcinoma spreads via shedding of cells and multicellular aggregates (MCAs) from the primary tumor into peritoneal cavity, with subsequent intraperitoneal tumor cell:mesothelial cell adhesion as a key early event in metastatic seeding. Evaluation of human tumor extracts and tissues confirms that well-differentiated ovarian tumors express abundant E-cadherin (Ecad), whereas advanced lesions...

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Share to Carcinoma, Ovarian Epithelial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Epithelial-Mesenchymal Transition

Share to Neoplasm Staging

Share to Neoplasms, Glandular and Epithelial

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Source

Open in PubMed Open full text

Identifiers

PMID: 28601643
DOI: 10.1016/j.neo.2017.04.002
PMCID: PMC5497527

Genes

CDH1
CDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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