Article
Association of TNFRSF4 gene polymorphisms with essential hypertension.
Journal of hypertension - 1 May 2008
Mashimo Yoichi, Suzuki Yoichi, Hatori Kazuko, Tabara Yasuharu, Miki Tetsuro, Tokunaga Katsushi, Katsuya Tomohiro, Ogihara Toshio, Yamada Michiko, Takahashi Norio, Makita Yoshio, Nakayama Tomohiro, Soma Masayoshi, Hirawa Nobuhito, Umemura Satoshi, Ohkubo Takayoshi, Imai Yutaka, Hata Akira
Abstract excerpt
BACKGROUND: Essential hypertension is a complex disorder that results from the interaction of a number of susceptibility genes and environmental factors. The TNFRSF4 (tumor necrosis factor receptor superfamily, member 4) gene was one of the genes that showed altered renal expression in long-term salt loading in mice. Moreover, association of the TNFRSF4 and TNFSF4 (tumor necrosis factor (ligand) superfamily,...
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