Article
A common polymorphism in the promoter region of the TNFSF4 gene is associated with lower allele-specific expression and risk of myocardial infarction.
PloS one - 18 Mar 2011
Ria Massimiliano, Lagercrantz Jacob, Samnegård Ann, Boquist Susanna, Hamsten Anders, Eriksson Per
Abstract excerpt
BACKGROUND: The TNFSF4/TNFRSF4 system, along with several other receptor-ligand pairs, is involved in the recruitment and activation of T-cells and is therefore tentatively implicated in atherosclerosis and acute coronary syndromes. We have previously shown that genetic variants in TNFSF4 are associated with myocardial infarction (MI) in women. This prompted functional studies of TNFSF4 expression. METHODS AND...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.