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Article

Var genes, strain hyperdiversity, and malaria transmission dynamics.

Trends in parasitology - 1 Jun 2025

Day Karen P, Tan Mun Hua, He Qixin, Ruybal-Pesántez Shazia, Zhan Qi, Tiedje Kathryn E, Pascual Mercedes

Abstract excerpt

The microbiological paradigm for surveillance of diverse pathogens requires knowledge of the variation of the major surface antigen under the most intense immune selection as immune responses to these antigens drive transmission dynamics. This creates a pathway for population genetics/genomics to be combined with mathematical modelling to describe transmission dynamics to inform public health policy. Here we...

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PMID: 40393890
DOI: 10.1016/j.pt.2025.04.010
PMCID: PMC12416208

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