Article
Upregulation of KCC2 activity by zinc-mediated neurotransmission via the mZnR/GPR39 receptor.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 7 Sept 2011
Chorin Ehud, Vinograd Ofir, Fleidervish Ilya, Gilad David, Herrmann Sharon, Sekler Israel, Aizenman Elias, Hershfinkel Michal
Abstract excerpt
Vesicular Zn(2+) regulates postsynaptic neuronal excitability upon its corelease with glutamate. We previously demonstrated that synaptic Zn(2+) acts via a distinct metabotropic zinc-sensing receptor (mZnR) in neurons to trigger Ca(2+) responses in the hippocampus. Here, we show that physiological activation of mZnR signaling induces enhanced K(+)/Cl(-) cotransporter 2 (KCC2) activity and surface expression. As...
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