Article
Bayesian meta-analysis of genetic association studies with different sets of markers.
American journal of human genetics - 1 Apr 2008
Verzilli Claudio, Shah Tina, Casas Juan P, Chapman Juliet, Sandhu Manjinder, Debenham Sally L, Boekholdt Matthijs S, Khaw Kay Tee, Wareham Nicholas J, Judson Richard, Benjamin Emelia J, Kathiresan Sekar, Larson Martin G, Rong Jian, Sofat Reecha, Humphries Steve E, Smeeth Liam, Cavalleri Gianpiero, Whittaker John C, Hingorani Aroon D
Abstract excerpt
Robust assessment of genetic effects on quantitative traits or complex-disease risk requires synthesis of evidence from multiple studies. Frequently, studies have genotyped partially overlapping sets of SNPs within a gene or region of interest, hampering attempts to combine all the available data. By using the example of C-reactive protein (CRP) as a quantitative trait, we show how linkage disequilibrium in and...
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