Article
Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study.
PLoS medicine - 1 Jun 2016
Prins Bram P, Abbasi Ali, Wong Anson, Vaez Ahmad, Nolte Ilja, Franceschini Nora, Stuart Philip E, Guterriez Achury Javier, Mistry Vanisha, Bradfield Jonathan P, Valdes Ana M, Bras Jose, Shatunov Aleksey, Lu Chen, Han Buhm, Raychaudhuri Soumya, Bevan Steve, Mayes Maureen D, Tsoi Lam C, Evangelou Evangelos, Nair Rajan P, Grant Struan F A, Polychronakos Constantin, Radstake Timothy R D, van Heel David A, Dunstan Melanie L, Wood Nicholas W, Al-Chalabi Ammar, Dehghan Abbas, Hakonarson Hakon, Markus Hugh S, Elder James T, Knight Jo, Arking Dan E, Spector Timothy D, Koeleman Bobby P C, van Duijn Cornelia M, Martin Javier, Morris Andrew P, Weersma Rinse K, Wijmenga Cisca, Munroe Patricia B, Perry John R B, Pouget Jennie G, Jamshidi Yalda, Snieder Harold, Alizadeh Behrooz Z
Abstract excerpt
BACKGROUND: C-reactive protein (CRP) is associated with immune, cardiometabolic, and psychiatric traits and diseases. Yet it is inconclusive whether these associations are causal. METHODS AND FINDINGS: We performed Mendelian randomization (MR) analyses using two genetic risk scores (GRSs) as instrumental variables (IVs). The first GRS consisted of four single nucleotide polymorphisms (SNPs) in the CRP gene...
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