Article
Genetics of rheumatoid arthritis - a comprehensive review.
Clinical reviews in allergy & immunology - 1 Oct 2013
Kurkó Júlia, Besenyei Timea, Laki Judit, Glant Tibor T, Mikecz Katalin, Szekanecz Zoltán
Abstract excerpt
The "Bermuda triangle" of genetics, environment and autoimmunity is involved in the pathogenesis of rheumatoid arthritis (RA). Various aspects of genetic contribution to the etiology, pathogenesis and outcome of RA are discussed in this review. The heritability of RA has been estimated to be about 60 %, while the contribution of HLA to heritability has been estimated to be 11-37 %. Apart from known shared epitope...
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