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Article

BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's disease

2 Apr 2014

Abstract excerpt

BACE1 (β-secretase, memapsin 2, Asp2) has emerged as a promising target for the treatment of Alzheimer's disease. BACE1 is an aspartic protease which functions in the first step of the pathway leading to the production and deposition of amyloid-β peptide (Aβ). Its gene deletion showed only mild phenotypes. BACE1 inhibition has direct implications in the Alzheimer's disease pathology without largely affecting...

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PMID: 24691405
DOI: 10.1039/c3cs60460h

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