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Article

Inflammatory responses of endothelial cells experiencing reduction in flow after conditioning by shear stress.

Journal of cellular physiology - 1 Sept 2008

Matharu Nick M, McGettrick Helen M, Salmon Mike, Kissane Steve, Vohra Rajiv K, Rainger G Ed, Nash Gerard B

Abstract excerpt

Exposure of endothelial cells (EC) to shear stress reduces their response to tumour necrosis factor-alpha (TNF). We tested how shear-conditioned EC responded to reduction in flow, either by spontaneously binding leukocytes, or by increasing sensitivity to TNF. Human umbilical vein EC were exposed to shear stress of 2.0 Pa (20 dyn/cm(2)) for 24 h. Shear was then reduced to stasis (30 sec perfusion each hour to...

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Share to Endothelial Cells
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Nitric Oxide Synthase

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Source

Identifiers

PMID: 18393276
DOI: 10.1002/jcp.21457

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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