Article

Low oscillatory shear stress regulates Weibel-Palade body size and vWF release

2023-05-26

Abstract excerpt

Blood flow regulates vascular function by generating wall shear stress which impacts endothelial cell (EC) physiology. Whilst high laminar shear stress (HSS) maintains the functional integrity of the vasculature, low oscillatory shear stress (LOSS) evokes secretion of pro-thrombotic and pro-inflammatory components from ECs, thus promoting the development of cardiovascular disease (CVD). Pro-thrombotic and pro-infl...

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Literature Corpus work: 7673ad8c-5e00-5f8e-b857-203aa30c56f3
DOI: 10.1101/2023.05.26.542527

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