Article
High-throughput mutation profiling in intraductal papillary mucinous neoplasm (IPMN).
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract - 1 Mar 2011
Lubezky Nir, Ben-Haim Menahem, Marmor Sylvia, Brazowsky Eli, Rechavi Gideon, Klausner Joseph M, Cohen Yoram
Abstract excerpt
BACKGROUND: Specific mutations leading to the development of various histological grades of intraductal papillary mucinous neoplasm (IPMN) have been partially characterized. METHODS: Analysis of 323 oncogenic mutations in 22 tumor-related genes was conducted, using a chip-based matrix-assisted laser desorption time-of-flight mass spectrometer of DNA extracted from microdissected cells of low-grade (n = 14),...
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