Article
p16 and p53 gene alterations and accumulations in the malignant evolution of intraductal papillary-mucinous tumors of the pancreas.
Journal of hepato-biliary-pancreatic surgery - 1 Jan 2002
Wada Keita
Abstract excerpt
BACKGROUND/PURPOSE: In general, intraductal papillary-mucinous tumors of the pancreas have a favorable prognosis. However, some invasive carcinomas show a rapid progression and a poor prognosis, such as invasive ductal carcinomas of the pancreas. The aim of this study was to clarify the genetic backgrounds underlying the evolution necessary for these tumors to become invasive carcinomas. METHODS: Twenty-three...
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