Article
Sequential accumulation of K-ras mutations and p53 overexpression in the progression of pancreatic mucinous cystic neoplasms to malignancy.
Annals of surgery - 1 Oct 1999
Jimenez R E, Warshaw A L, Z'graggen K, Hartwig W, Taylor D Z, Compton C C, Fernández-del Castillo C
Abstract excerpt
OBJECTIVE: Pancreatic mucinous cystic neoplasms (MCNs) provide a spectrum of neoplastic changes ranging from benign to malignant. The authors have correlated K-ras mutations and p53 overexpression with the evolution of these tumors. METHODS: Areas of mild, moderate, or severe dysplasia were microdissected from paraffin-embedded tissue sections of 28 different MCNs (10 benign, 9 borderline, 9 malignant)....
Topics
- DNA Mutational Analysis
- Disease Progression
- Gene Expression Regulation, Neoplastic
- Genes, p53
- Genes, ras
- Humans
- Immunohistochemistry
- Mutation
- Neoplasms, Cystic, Mucinous, and Serous
- Pancreatic Neoplasms