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Article

Sequential accumulation of K-ras mutations and p53 overexpression in the progression of pancreatic mucinous cystic neoplasms to malignancy.

Annals of surgery - 1 Oct 1999

Jimenez R E, Warshaw A L, Z'graggen K, Hartwig W, Taylor D Z, Compton C C, Fernández-del Castillo C

Abstract excerpt

OBJECTIVE: Pancreatic mucinous cystic neoplasms (MCNs) provide a spectrum of neoplastic changes ranging from benign to malignant. The authors have correlated K-ras mutations and p53 overexpression with the evolution of these tumors. METHODS: Areas of mild, moderate, or severe dysplasia were microdissected from paraffin-embedded tissue sections of 28 different MCNs (10 benign, 9 borderline, 9 malignant)....

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Share to Disease Progression
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Genes, p53

Share to Genes, ras

Share to Immunohistochemistry

Share to Neoplasms, Cystic, Mucinous, and Serous

Share to Pancreatic Neoplasms

Source

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Identifiers

PMID: 10522720
DOI: 10.1097/00000658-199910000-00006
PMCID: PMC1420899

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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