Article
5-Lipoxygenase activating protein (ALOX5AP) gene variants associate with the presence of xanthomas in familial hypercholesterolemia.
Atherosclerosis - 1 Sept 2009
Oosterveer Daniëlla M, Versmissen Jorie, Yazdanpanah Mojgan, van der Net Jeroen B, Defesche Joep C, Kastelein John J P, Sijbrands Eric J G
Abstract excerpt
BACKGROUND: Tendon xanthomas are characteristic for familial hypercholesterolemia (FH), and are associated with a higher risk of coronary heart disease (CHD). They often present with local inflammation. Inflammation may therefore be involved in their pathogenesis, as it is in the pathogenesis of CHD. A key role in the inflammatory pathway is played by the 5-lipoxygenase activating protein (ALOX5AP), which is...
Topics
- 5-Lipoxygenase-Activating Proteins
- Adult
- Arachidonate 5-Lipoxygenase
- Carrier Proteins
- Female
- Genetic Predisposition to Disease
- Haplotypes
- Humans
- Hyperlipoproteinemia Type II
- Male
- Membrane Proteins
- Middle Aged
- Polymorphism, Genetic