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Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage

5 Jul 2017

Abstract excerpt

Today, it is known that autoimmune diseases start a long time before clinical symptoms appear. Anti-citrullinated protein antibodies (ACPAs) appear many years before the clinical onset of rheumatoid arthritis (RA). However, it is still unclear if and how ACPAs are arthritogenic. To better understand the molecular basis of pathogenicity of ACPAs, we investigated autoantibodies reactive against the C1 epitope of...

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PMID: 28679953
DOI: 10.1172/jci.insight.93688

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