Article
Presence and role of anti-citrullinated protein antibodies in experimental arthritis models.
Arthritis and rheumatism - 1 Apr 2013
Cantaert Tineke, Teitsma Christine, Tak Paul P, Baeten Dominique
Abstract excerpt
OBJECTIVE: Anti-citrullinated protein antibodies (ACPAs) are the serologic hallmark of rheumatoid arthritis. Functional studies on the role of ACPAs in experimental arthritis have yielded conflicting results, and therefore the present study was undertaken to assess systematically whether citrullinated proteins can really induce ACPAs and modulate arthritis in mice. METHODS: Balb/c, SJL, and DBA/1 mice were...
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