BCOR Mutations Identify a Clinically Aggressive Subset of Pediatric Rhabdomyosarcoma.

Abstract excerpt

Background: BCOR mutations occur in about 5% in pediatric rhabdomyosarcoma (RMS), their clinical significance and mechanistic roles remain undefined. This study characterizes BCOR-mutant RMS as a molecularly distinct, high-risk subgroup. Methods: Multimodal analysis of four pediatric embryonal RMS cases with BCOR mutations, integrating histopathology, immunohistochemistry, genomic profiling, and clinical...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Child
• Share to Child, Preschool
• Share to BCOR gene