Article
Molecular classification of rhabdomyosarcoma--genotypic and phenotypic determinants of diagnosis: a report from the Children's Oncology Group.
The American journal of pathology - 1 Feb 2009
Davicioni Elai, Anderson Michael J, Finckenstein Friedrich Graf, Lynch James C, Qualman Stephen J, Shimada Hiroyuki, Schofield Deborah E, Buckley Jonathan D, Meyer William H, Sorensen Poul H B, Triche Timothy J
Abstract excerpt
Rhabdomyosarcoma (RMS) in children occurs as two major histological subtypes, embryonal (ERMS) and alveolar (ARMS). ERMS is associated with an 11p15.5 loss of heterozygosity (LOH) and may be confused with nonmyogenic, non-RMS soft tissue sarcomas. ARMS expresses the product of a genomic translocation that fuses FOXO1 (FKHR) with either PAX3 or PAX7 (P-F); however, at least 25% of cases lack these translocations....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.