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Article

Maternal environment interacts with modifier genes to influence progression of nephrotic syndrome.

Journal of the American Society of Nephrology : JASN - 1 Aug 2008

Ratelade Julien, Lavin Tiphaine Aguirre, Muda Andrea Onetti, Morisset Ludivine, Mollet Géraldine, Boyer Olivia, Chen Deborah S, Henger Anna, Kretzler Matthias, Hubner Norbert, Théry Clotilde, Gubler Marie-Claire, Montagutelli Xavier, Antignac Corinne, Esquivel Ernie L

Abstract excerpt

Mutations in the NPHS2 gene, which encodes podocin, are responsible for some cases of sporadic and familial autosomal recessive steroid-resistant nephrotic syndrome. Inter- and intrafamilial variability in the progression of renal disease among patients bearing NPHS2 mutations suggests a potential role for modifier genes. Using a mouse model in which the podocin gene is constitutively inactivated, we sought to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18385421
DOI: 10.1681/ASN.2007111268
PMCID: PMC2488258

Genes

NPHS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Maternal environment interacts with modifier genes to influence progression of nephrotic syndrome.PMID 18385421Read ↗

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