Article
Kidneys with heavy proteinuria show fibrosis, inflammation, and oxidative stress, but no tubular phenotypic change.
Kidney international - 1 Jul 2005
Kuusniemi Arvi-Matti, Lapatto Risto, Holmberg Christer, Karikoski Riitta, Rapola Juhani, Jalanko Hannu
Abstract excerpt
BACKGROUND: Sustained proteinuria is a major factor leading to kidney fibrosis and end-stage renal failure. Tubular epithelial cells are believed to play a crucial role in this process by producing mediators leading to fibrosis and inflammation. Congenital nephrotic syndrome of the Finnish type (NPHS1) is a genetic disease caused by mutations in a podocyte protein nephrin, which leads to constant heavy...
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