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Article

Interaction with Podocin Facilitates Nephrin Signaling

1 Nov 2001

Abstract excerpt

Mutations of NPHS1 or NPHS2, the genes encoding for the glomerular podocyte proteins nephrin and podocin, cause steroid-resistant proteinuria. In addition, mice lacking CD2-associated protein (CD2AP) develop a nephrotic syndrome that resembles NPHS mutations suggesting that all three proteins are essential for the integrity of glomerular podocytes. Although the precise glomerular function of either protein...

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Identifiers

PMID: 11562357
DOI: 10.1074/jbc.c100452200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Interaction with Podocin Facilitates Nephrin SignalingPMID 11562357Read ↗

Nephrin Signaling in the Podocyte: An Updated View of Signal Regulation at the Slit Diaphragm and BeyondSemantic proximity Read ↗

Molecular basis of the functional podocin-nephrin complex: mutations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomains.Semantic proximity Read ↗

Revisiting nephrin signaling and its specialized effects on the uniquely adaptable podocyteSemantic proximity Read ↗

NEPH1 defines a novel family of podocin‐interacting proteinsSemantic proximity Read ↗

Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes.Semantic proximity Read ↗

An update: the role of Nephrin inside and outside the kidneySemantic proximity Read ↗

Nephrin-signature molecule of the glomerular podocyte?Semantic proximity Read ↗

Lmx1b and FoxC combinatorially regulate podocin expression in podocytes.Semantic proximity Read ↗

Nephrin – a unique structural and signaling protein of the kidney filterSemantic proximity Read ↗

Phosphorylation of key podocyte proteins and the association with proteinuric kidney diseaseSemantic proximity Read ↗

Mapping of the podocin proximity-dependent proteome reveals novel components of the kidney podocyte foot processSemantic proximity Read ↗

CD2AP is expressed with nephrin in developing podocytes and is found widely in mature kidney and elsewhere.Semantic proximity Read ↗

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