Metabotropic NMDA Receptor Signaling Contributes to Sex Differences in Synaptic Plasticity and Episodic Memory

Abstract excerpt

<h4>Summary</h4> Men generally outperform women on encoding spatial components of episodic memory whereas the reverse holds for semantic elements. Here we show that female mice outperform males on tests for non-spatial aspects of episodic memory (“what”, “when”), suggesting that the human findings are influenced by neurobiological factors common to mammals. Analysis of hippocampal synaptic plasticity mechanisms a...

Topics

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• Excitatory Amino Acid Antagonists
• Long-Term Potentiation
• Memory
• Models, Animal
• Molecular Biology
• Neuronal Plasticity
• Receptors, AMPA
• Receptors, N-Methyl-D-Aspartate

Identifiers and source

Literature Corpus work

13c91d36-e39e-5c91-bb67-02aa153ebe42

DOI

10.1101/2024.01.26.577478