Article
The tumour necrosis factor receptor superfamily member 1b 676T>G polymorphism in relation to response to infliximab and adalimumab treatment and disease severity in rheumatoid arthritis.
Annals of the rheumatic diseases - 1 Aug 2008
Toonen E J M, Coenen M J H, Kievit W, Fransen J, Eijsbouts A M, Scheffer H, Radstake T R D J, Creemers M C W, de Rooij D-J R A M, van Riel P L C M, Franke B, Barrera P
Abstract excerpt
OBJECTIVE: To assess the effect of a functional polymorphism (676T>G, M196R) in the tumour necrosis factor receptor super family 1b (TNFSF1b) gene on disease activity, radiological joint damage and response to infliximab and adalimumab treatment in patients with rheumatoid arthritis (RA). METHODS: Two cohorts of patients with RA were genotyped for the 676T>G polymorphism (rs1061622) in exon 6 of the TNFSF1b gene...
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