Article
Genetic variants within the TNFRSF1B gene and susceptibility to rheumatoid arthritis and response to anti-TNF drugs: a multicenter study.
Pharmacogenetics and genomics - 1 Jul 2015
Canet Luz M, Filipescu Ileana, Cáliz Rafael, Lupiañez Carmen B, Canhão Helena, Escudero Alejandro, Segura-Catena Juana, Soto-Pino María J, Ferrer Miguel A, García Antonio, Romani Lurdes, Pérez-Pampin Eva, González-Utrilla Alfonso, López Nevot Miguel A, Collantes Eduardo, Fonseca João E, Sainz Juan
Abstract excerpt
BACKGROUND: Recent research suggests that genetic variants in the tumor necrosis factor receptor 2 (TNFRSF1B) gene may have an impact on susceptibility to rheumatoid arthritis (RA) and drug response. The present population-based case-control study was carried out to evaluate whether 5 tagging single-nucleotide polymorphisms (SNPs) within the TNFRSF1B gene are associated with the risk of RA and response to...
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