Article
CD6 and syntaxin binding protein 6 variants and response to tumor necrosis factor alpha inhibitors in Danish patients with rheumatoid arthritis.
PloS one - 1 Jan 2012
Krintel Sophine B, Essioux Laurent, Wool Assaf, Johansen Julia S, Schreiber Ehud, Zekharya Tomer, Akiva Pinchas, Ostergaard Mikkel, Hetland Merete L
Abstract excerpt
BACKGROUND: TNFα inhibitor therapy has greatly improved the treatment of patients with rheumatoid arthritis, however at least 30% do not respond. We aimed to investigate insertions and deletions (INDELS) associated with response to TNFα inhibitors in patients with rheumatoid arthritis (RA). METHODOLOGY AND PRINCIPAL FINDINGS: In the DANBIO Registry we identified 237 TNFα inhibitor naïve patients with RA (81%...
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