Article
Analysis of associations between polymorphisms within genes coding for tumour necrosis factor (TNF)-alpha and TNF receptors and responsiveness to TNF-alpha blockers in patients with rheumatoid arthritis.
Joint bone spine - 1 Mar 2015
Swierkot Jerzy, Bogunia-Kubik Katarzyna, Nowak Beata, Bialowas Katarzyna, Korman Lucyna, Gebura Katarzyna, Kolossa Katarzyna, Jeka Slawomir, Wiland Piotr
Abstract excerpt
INTRODUCTION: Despite the fact that therapy with TNF-α inhibitors constitutes a breakthrough in rheumatoid arthritis management, no improvement is still achieved in approximately 30% of cases. The aim of the study was to evaluate whether single nucleotide polymorphisms (SNPs) within the TNF-α and TNF receptor encoding genes affect the efficacy of therapy with TNF-α inhibitors in patients with RA. METHODS: Five...
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