Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLR1) with CAD.

BMC medical genetics - 2 Apr 2008

Knowles Joshua W, Assimes Themistocles L, Boerwinkle Eric, Fortmann Stephen P, Go Alan, Grove Megan L, Hlatky Mark, Iribarren Carlos, Li Jun, Myers Richard, Risch Neil, Sidney Stephen, Southwick Audrey, Volcik Kelly A, Quertermous Thomas

Abstract excerpt

BACKGROUND: The lectin-like oxidized LDL receptor LOX-1 (encoded by OLR1) is believed to play a key role in atherogenesis and some reports suggest an association of OLR1 polymorphisms with myocardial infarction (MI). We tested whether single nucleotide polymorphisms (SNPs) in OLR1 are associated with clinically significant CAD in the Atherosclerotic Disease, VAscular FuNction, & Geneti C Epidemiology (ADVANCE)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies
Share to Coronary Artery Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to LOX gene

Share to Genetic Predisposition to Disease

Share to Genotype

Share to Polymorphism, Single Nucleotide

Share to Reproducibility of Results

Share to Scavenger Receptors, Class E

Source

Open in PubMed Open full text

Identifiers

PMID: 18384690
DOI: 10.1186/1471-2350-9-23
PMCID: PMC2322963

Genes

CAD
OLR1
LOX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLR1) with CAD.PMID 18384690Read ↗

Association of OLR1 gene polymorphisms with the risk of coronary artery disease: A systematic review and meta-analysis.Semantic proximity Read ↗

Genetic variation in lectin-like oxidized low-density lipoprotein receptor 1 (LOX1) gene and the risk of coronary artery disease.Semantic proximity Read ↗

Common polymorphisms of ALOX5 and ALOX5AP and risk of coronary artery disease.Semantic proximity Read ↗

Genome-wide association study pinpoints a new functional apolipoprotein B variant influencing oxidized low-density lipoprotein levels but not cardiovascular events: AtheroRemo Consortium.Semantic proximity Read ↗

Scavenger Receptor LOX1 Genotype Predicts Coronary Artery Disease in Patients With Familial Hypercholesterolemia.Semantic proximity Read ↗

LOX-1 variants modulate the severity of cardiovascular disease: state of the art and future directions.Semantic proximity Read ↗

The human rs1050286 polymorphism alters LOX-1 expression through modifying miR-24 binding.Semantic proximity Read ↗

Oxidized LDL receptor gene (OLR1) is associated with the risk of myocardial infarction.Semantic proximity Read ↗

G501C polymorphism of oxidized LDL receptor gene (OLR1) and ischemic stroke.Semantic proximity Read ↗

No large-effect low-frequency coding variation found for myocardial infarction.Semantic proximity Read ↗

Common genetic variants do not associate with CAD in familial hypercholesterolemia.Semantic proximity Read ↗

Lack of association of genetic variants in the LRP8 gene with familial and sporadic myocardial infarction.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.