Article
Common genetic variants do not associate with CAD in familial hypercholesterolemia.
European journal of human genetics : EJHG - 1 Jun 2014
van Iperen Erik P A, Sivapalaratnam Suthesh, Boekholdt S Matthijs, Hovingh G Kees, Maiwald Stephanie, Tanck Michael W, Soranzo Nicole, Stephens Jonathan C, Sambrook Jennifer G, Levi Marcel, Ouwehand Willem H, Kastelein John Jp, Trip Mieke D, Zwinderman Aeilko H
Abstract excerpt
In recent years, multiple loci dispersed on the genome have been shown to be associated with coronary artery disease (CAD). We investigated whether these common genetic variants also hold value for CAD prediction in a large cohort of patients with familial hypercholesterolemia (FH). We genotyped a total of 41 single-nucleotide polymorphisms (SNPs) in 1701 FH patients, of whom 482 patients (28.3%) had at least one...
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