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Article

Lack of association of genetic variants in the LRP8 gene with familial and sporadic myocardial infarction.

Journal of molecular medicine (Berlin, Germany) - 1 Oct 2008

Lieb Wolfgang, Zeller Tanja, Mangino Massimo, Götz Anika, Braund Peter, Wenzel Juergen J, Horn Christian, Proust Carole, Linsel-Nitschke Patrick, Amouyel Philippe, Bruse Petra, Arveiler Dominique, König Inke R, Ferrières Jean, Ziegler Andreas, Balmforth Anthony J, Evans Alun, Ducimetière Pierre, Cambien Francois, Hengstenberg Christian, Stark Klaus, Hall Alistair S, Schunkert Heribert, Blankenberg Stefan, Samani Nilesh J, Erdmann Jeanette, Tiret Laurence

Abstract excerpt

Coronary artery disease (CAD) and myocardial infarction (MI) have a genetic basis, but the precise genetic underpinning remains controversial. Recently, an association of the LRP8 R952Q polymorphism (rs5174) with familial premature CAD/MI was reported. We analysed rs5174 (or the perfect proxy rs5177) in 1,210 patients with familial MI and 1,015 controls from the German MI Family study, in 1,926 familial CAD...

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Source

Identifiers

PMID: 18592168
DOI: 10.1007/s00109-008-0376-5

Genes

CAD
LRP8

Variants

rs5174

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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