Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activation of -catenin signaling by Rspo1 controls differentiation of the mammalian ovary

18 Jan 2008

Abstract excerpt

The sex of an individual is determined by the fate of the gonad. While the expression of Sry and Sox9 is sufficient to induce male development, we here show that female differentiation requires activation of the canonical beta-catenin signaling pathway. beta-catenin activation is controlled by Rspo1 in XX gonads and Rspo1 knockout mice show masculinized gonads. Molecular analyses demonstrate an absence of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Reproductive Biology and Fertility
Share to Sexual Differentiation and Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18250098
DOI: 10.1093/hmg/ddn016

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activation of -catenin signaling by Rspo1 controls differentiation of the mammalian ovaryPMID 18250098Read ↗

Testicular Differentiation Occurs in Absence of R-spondin1 and Sox9 in Mouse Sex ReversalsSemantic proximity Read ↗

R-spondin1, WNT4, and the CTNNB1 signaling pathway: strict control over ovarian differentiationSemantic proximity Read ↗

Genetics of Ovarian Differentiation: <i>Rspo1</i>, a Major PlayerSemantic proximity Read ↗

Sox8 and Sox9 act redundantly for ovarian-to-testicular fate reprogramming in the absence of R-spondin1 in mouse sex reversalsSemantic proximity Read ↗

R-spondin1 plays an essential role in ovarian development through positively regulating Wnt-4 signalingSemantic proximity Read ↗

WNT4 and RSPO1 together are required for cell proliferation in the early mouse gonadSemantic proximity Read ↗

<i>Sox8</i> and <i>Sox9</i> act redundantly for ovarian-to-testicular fate reprogramming in the absence of <i>R-spondin1</i> in mouse sex reversalsSemantic proximity Read ↗

Sex-specific roles of -catenin in mouse gonadal developmentSemantic proximity Read ↗

Human RSPO1/R-spondin1 Is Expressed during Early Ovary Development and Augments β-Catenin SignalingSemantic proximity Read ↗

RSPO1/β-catenin signaling pathway regulates oogonia differentiation and entry into meiosis in the mouse fetal ovary.Semantic proximity Read ↗

Deciphering Sex-Specific Differentiation of Human Fetal Gonads: Insight From Experimental ModelsSemantic proximity Read ↗

Disruption of mitotic arrest precedes precocious differentiation and transdifferentiation of pregranulosa cells in the perinatal Wnt4 mutant ovary.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.