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Article

Biallelic somatic inactivation of the mismatch repair gene MLH1 in a primary skin melanoma.

Genes, chromosomes & cancer - 1 Jun 2003

Castiglia Daniele, Pagani Elena, Alvino Ester, Vernole Patrizia, Marra Giancarlo, Cannavò Elda, Jiricny Josef, Zambruno Giovanna, D'Atri Stefania

Abstract excerpt

Inactivation of mismatch repair (MMR) genes has been linked to the hereditary nonpolyposis colon cancer syndrome and to a subset of sporadic cancers. A phenotypic characteristic of tumors with defective MMR is microsatellite instability (MSI). Although MSI has been reported in a proportion of cutaneous melanomas, inactivation of MMR genes in this tumor type has not been detected thus far. We recently described a...

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Share to Base Pair Mismatch
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colonic Neoplasms

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Source

Identifiers

PMID: 12696065
DOI: 10.1002/gcc.10193

Genes

MLH1
PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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