Article
A new single nucleotide polymorphism in XRCC4 gene is associated with breast cancer susceptibility in Taiwanese patients.
Anticancer research - 1 Jan 2000
Chiu Chang-Fang, Wang Hwei-Chung, Wang Chung-Hsing, Wang Cheng-Li, Lin Cheng-Chieh, Shen Chen-Yang, Chiang Su-Yin, Bau Da-Tian
Abstract excerpt
BACKGROUND: The DNA repair gene XRCC4, an important caretaker of the overall genome stability, is thought to play a major role in the human carcinogenesis. Some new and important polymorphic variants of XRCC4, at codon 247 (rs 3734091), G-1394T (rs 6869366), and Intron 7 (rs 28360317), and their association with breast cancer susceptibility was investigated in a Taiwanese population. MATERIALS AND METHODS: In a...
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