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Article

A functional -77T>C polymorphism in XRCC1 is associated with risk of breast cancer.

Breast cancer research and treatment - 1 Jan 2011

Liu Li, Yuan Peng, Liu Li, Wu Chen, Zhang Xiaomin, Guo Huan, Zhong Rong, Xu Yihua, Wu Jing, Duan Shengyu, Rui Rui, Wu Tangchun, Nie Shaofa, Miao Xiaoping, Lin Dongxin

Abstract excerpt

X-ray repair cross-complementing 1 (XRCC1) plays a critical role in base excision repair and genetic variations of XRCC1 may be associated with cancer susceptibility. We tested this hypothesis by examining the contribution of polymorphism in the regulatory region of XRCC1 -77T>C to risk of breast cancer in 995 patients and 1,004 controls. We found this polymorphism was associated with an increased risk of breast...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20549339
DOI: 10.1007/s10549-010-0959-z

Genes

XRCC1

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