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Article

A recessive variant of XRCC4 predisposes to non- BRCA1/2 breast cancer in chinese women and impairs the DNA damage response via dysregulated nuclear localization.

Oncotarget - 15 Dec 2014

He Min, Hu Xin, Chen Li, Cao A-Yong, Yu Ke-Da, Shi Ting-Yan, Kuang Xia-Ying, Shi Wen-Biao, Ling Hong, Li Shan, Qiao Feng, Yao Ling, Wei Qingyi, Di Gen-Hong, Shao Zhi-Ming

Abstract excerpt

XRCC4 plays a crucial role in the non-homologous end joining pathway that maintains genome stability. In this two-stage case-control study with 1,764 non-BRCA1/2 breast cancer patients and 1,623 cancer-free controls, we investigated the contribution of genetic variants of XRCC4 to breast cancer s...

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Source

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Identifiers

PMID: 25360583
DOI: 10.18632/oncotarget.2623
PMCID: PMC4322983

Genes

XRCC4
BRCA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25360583-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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