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Article

WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase.

Genes & development - 1 Apr 2008

Hu Jian, Zacharek Sima, He Yizhou Joseph, Lee Hyun, Shumway Stuart, Duronio Robert J, Xiong Yue

Abstract excerpt

Tuberous sclerosis (TSC) is an autosomal dominant disease characterized by hamartoma formation in various organs and is caused by mutations targeting either the TSC1 or TSC2 genes. TSC1 and TSC2 proteins form a functionally interdependent dimeric complex. Phosphorylation of either TSC subunit by different kinases regulates the function of TSC and represents a major mechanism to integrate various signals into a...

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Source

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Identifiers

PMID: 18381890
DOI: 10.1101/gad.1624008
PMCID: PMC2279197

Genes

TSC2
DDB1
TSC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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