Article
Neuromedin U signaling regulates retrieval of learned salt avoidance in a C. elegans gustatory circuit.
Nature communications - 29 Apr 2020
Watteyne Jan, Peymen Katleen, Van der Auwera Petrus, Borghgraef Charline, Vandewyer Elke, Van Damme Sara, Rutten Iene, Lammertyn Jeroen, Jelier Rob, Schoofs Liliane, Beets Isabel
Abstract excerpt
Learning and memory are regulated by neuromodulatory pathways, but the contribution and temporal requirement of most neuromodulators in a learning circuit are unknown. Here we identify the evolutionarily conserved neuromedin U (NMU) neuropeptide family as a regulator of C. elegans gustatory aversive learning. The NMU homolog CAPA-1 and its receptor NMUR-1 are required for the retrieval of learned salt avoidance....
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