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Article

Methotrexate (MTX) pathway gene polymorphisms and their effects on MTX toxicity in Caucasian and African American patients with rheumatoid arthritis.

The Journal of rheumatology - 1 Apr 2008

Ranganathan Prabha, Culverhouse Robert, Marsh Sharon, Mody Ami, Scott-Horton Tiffany J, Brasington Richard, Joseph Amy, Reddy Virginia, Eisen Seth, McLeod Howard L

Abstract excerpt

OBJECTIVE: Research has examined the association of folate-dependent gene polymorphisms with methotrexate (MTX) toxicity in racially homogenous patients with rheumatoid arthritis (RA). We examined the influence of MTX transporter gene polymorphisms on MTX toxicity in 2 racial groups of patients with RA. METHODS: Using a retrospective cross-validation approach, the association of polymorphisms in 6 genes in the...

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Source

Identifiers

PMID: 18381794

Genes

ABCC2
MTHFR
ABCB1
ABCC1
FPGS
TYMS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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